http://hdl.handle.net/11531/5 Tesis, Artículos, Capítulos de Libros, Papers, ... 2026-04-29T02:30:21Z http://hdl.handle.net/11531/109803 Título : Las medidas no privativas de libertad en la justicia juvenil española Autor : Cueto Santa Eugenia, Elisabet Resumen : El trabajo analiza el sistema de justicia juvenil español con especial atención a las medidas no privativas de libertad previstas en la Ley Orgánica de Responsabilidad Penal de los Menores (LORPM), situándolas dentro del marco de los estándares internacionales y regionales de protección de los derechos del niño. La investigación parte del principio del interés superior del menor como eje vertebrador del sistema, recogido en la Convención sobre los Derechos del Niño y desarrollado por la normativa y la jurisprudencia española. El estudio examina los principios que orientan la determinación de las medidas, como la legalidad, la proporcionalidad, la individualización y la finalidad educativa de la respuesta penal juvenil. Se destaca que, a diferencia del sistema penal de adultos, la LORPM otorga al juez un amplio margen de discrecionalidad reglada para adaptar la respuesta a las circunstancias personales, familiares y sociales del menor, con el apoyo fundamental de los equipos técnicos especializados. Asimismo, se describen las distintas medidas no privativas de libertad, subrayando su carácter educativo, rehabilitador y orientado a la reinserción social. El análisis jurisprudencial pone de manifiesto que las Audiencias Provinciales refuerzan esta orientación, priorizando alternativas al internamiento y promoviendo intervenciones ajustadas a las necesidades concretas de cada menor. En conclusión, el sistema español se presenta como un modelo coherentemente alineado con los estándares internacionales de justicia juvenil.; This work analyses the Spanish juvenile justice system with a particular focus on non-custodial measures regulated under the Organic Law on the Criminal Responsibility of Minors (LORPM), placing them within the framework of international and regional child rights standards. The study is grounded on the principle of the best interests of the child, established in the Convention on the Rights of the Child and consistently reflected in Spanish legislation and case law. The paper examines the guiding principles for determining juvenile measures, including legality, proportionality, individualisation and the educational purpose of juvenile sanctions. Unlike the adult criminal system, the LORPM grants juvenile judges a broad but regulated discretion, allowing them to tailor measures to the personal, social and family circumstances of each minor, with significant input from specialised technical teams. The various non-custodial measures are described, highlighting their educational, rehabilitative and reintegrative objectives. A review of Spanish case law shows that Provincial Courts strongly support alternatives to deprivation of liberty and promote individualised responses aimed at personal development and social reintegration. Overall, the analysis concludes that the Spanish juvenile justice system is largely aligned with international standards, emphasising education, rehabilitation and the prevention of reoffending. Descripción : Capítulos en libros 2026-04-08T00:00:00Z http://hdl.handle.net/11531/109801 Título : Adult Zucker Obese fa/fa Rats Present Impaired Immunity and Oxidative-Inflammatory Responses Autor : Castro de Frutos, Nuria María de; de la Fuente, Mónica; Gimenez Llort, Lydia; RUIZ-TOVAR POLO, JAIME; Vidal Real, Carmen; Baeza Monedero, Isabel Resumen : .; first_pagesettingsOrder Article Reprints Open AccessArticle Adult Zucker Obese fa/fa Rats Present Impaired Immunity and Oxidative-Inflammatory Responses by Nuria María De Castro 1,2,*ORCID,Mónica De la Fuente 3,4ORCID,Lydia Giménez-Llort 5,6ORCID,Jaime Ruiz-Tovar 7ORCID,Carmen Vida 8,9ORCID andMaría Isabel Baeza 1,2ORCID 1 Health Sciences Department, San Juan de Dios School of Nursing and Physical Therapy, Comillas Pontifical University, 28036 Madrid, Spain 2 San Juan de Dios Foundation, 28036 Madrid, Spain 3 Department of Genetics, Physiology and Microbiology (Unit of Animal Physiology), Complutense University of Madrid, 28040 Madrid, Spain 4 Institute of Investigation 12 de Octubre Hospital (Imas12), 28041 Madrid, Spain 5 Department of Psychiatry and Forensic Medicine, School of Medicine, Autonomous University of Barcelona, 08193 Barcelona, Spain 6 Institute of Neuroscience (INc), Autonomous University of Barcelona, 08193 Barcelona, Spain 7 Department of Biomedicine and Health Sciences, Alfonso X University, 28691 Madrid, Spain 8 Department of Biology (Animal Physiology Area), Faculty of Sciences, Autonomous University of Madrid, 28049 Madrid, Spain 9 University Institute of Molecular Biology (IUBM), Autonomous University of Madrid, 28049 Madrid, Spain * Author to whom correspondence should be addressed. Biomolecules 2026, 16(4), 547; https://doi.org/10.3390/biom16040547 Submission received: 25 February 2026 / Revised: 25 March 2026 / Accepted: 31 March 2026 / Published: 8 April 2026 (This article belongs to the Special Issue Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities) Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract Background: Obesity involves an excessive buildup of adipose tissue and is linked to chronic inflammation and oxidative stress, both of which contribute to immunosenescence. Obesity and aging share common features, including immune system impairment and oxidative and inflammatory states, suggesting that obesity may represent a model for accelerated immunosenescence. Objectives/Methods: The aim of this research was to evaluate in Zucker fatty (fa/fa) rats, a well-established genetic model of obesity, multiple immune function parameters (phagocytic activity, natural killer cell function, lymphocyte proliferation in response to mitogens, and cytokine profiles), as well as redox parameters (total antioxidant capacity, glutathione levels, activities of glutathione peroxidase and reductase, and xanthine oxidase activity) in peritoneal leukocytes, spleen, thymus, and liver at adult age (24 weeks). Comparisons were made with Zucker lean controls (fa/+), commonly used as standard controls, and Wistar rats as an independent control group. Results: Zucker fa/fa rats displayed significant physiological disorders, including increased body and organ weights, premature immunosenescence characterized by impaired innate and adaptive immune responses, reduced IL-2 and IL-10 secretion, elevated TNF-α production upon mitogen stimulation, and oxidative stress evidenced by redox imbalance in the spleen, thymus, and liver. Conclusions: These immune dysfunctions and oxidative imbalances are comparable to those observed during the aging process. Given that the immune parameters analyzed are considered indicators of health, aging rate, and longevity, our findings suggest that adult Zucker fa/fa rats could exhibit features of premature aging. Descripción : Artículos en revistas 2026-04-08T00:00:00Z http://hdl.handle.net/11531/109796 Título : La Democracia Digital del siglo XXI Autor : Arévalo Gutiérrez, Alfonso; Burzaco Samper, María; Collado Martínez, Rosa María; García Caba, Miguel María; García De Cal, José Luis; Jerez Calderón, José Joaquín; Lavilla Rubira, Juan José; López de la Osa Escribano, Pilar; Rodríguez Villar, Beatriz Gemma; Tarlea Jiménez, Rocío; Villegas Moreno, José Luis Resumen : La obra analiza la transformación de la democracia en el contexto de la digitalización, abordando el impacto de las tecnologías en las instituciones públicas, la participación ciudadana y el ejercicio del poder. A través de distintos capítulos, se examinan cuestiones como la tecnopolítica, la administración digital, la transparencia, la inteligencia artificial, la desinformación y la participación política en entornos digitales. El libro destaca cómo el ciberespacio y los algoritmos reconfiguran los conceptos tradicionales de soberanía, jurisdicción y responsabilidad, generando nuevos desafíos jurídicos. Asimismo, se estudia el papel de la Unión Europea en la regulación digital y la necesidad de garantizar los derechos fundamentales en un entorno dominado por plataformas tecnológicas y flujos masivos de datos.; This work analyzes the transformation of democracy in the context of digitalization, addressing the impact of technologies on public institutions, citizen participation, and the exercise of power. Through various chapters, it examines issues such as technopolitics, digital administration, transparency, artificial intelligence, disinformation, and political participation in digital environments. The book highlights how cyberspace and algorithms reshape traditional concepts of sovereignty, jurisdiction, and responsibility, creating new legal challenges. It also explores the role of the European Union in digital regulation and the need to safeguard fundamental rights in an environment dominated by technological platforms and massive data flows. Descripción : Libro de Investigación 2026-03-30T00:00:00Z http://hdl.handle.net/11531/109795 Título : Conciencia y mismidad Autor : Blanco Pérez, Carlos Alberto Resumen : La obra aborda una reflexión filosófica profunda sobre la conciencia humana y la noción de “mismidad”, entendida como lo dado o lo que comparece en el mundo. El autor examina la capacidad del pensamiento para trascender esa mismidad y generar novedad, defendiendo que pensar implica cuestionar, crear y abrir horizontes futuros. El libro dialoga con la tradición filosófica y el desarrollo científico contemporáneo, analizando las tensiones entre ciencia y filosofía, naturaleza y cultura, determinismo y libertad. A lo largo de sus capítulos, se exploran temas como la subjetividad, la libertad, la creatividad, la historia y la solidaridad, proponiendo que la conciencia humana es esencialmente un desafío a lo dado y una fuerza creadora capaz de transformar la realidad.; This book offers a profound philosophical reflection on human consciousness and the notion of “selfhood” (mismidad), understood as what is given in the world. The author examines the capacity of thought to transcend this given reality and generate novelty, arguing that thinking involves questioning, creating, and opening new horizons. The work engages both the philosophical tradition and contemporary scientific developments, analyzing tensions between science and philosophy, nature and culture, determinism and freedom. Throughout its chapters, it explores themes such as subjectivity, freedom, creativity, history, and solidarity, proposing that human consciousness fundamentally challenges what is given and acts as a creative force capable of transforming reality. Descripción : Libro de Investigación 2026-04-09T00:00:00Z