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Mostrando ítems 1-20 de 103
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A child’s play: an agent-based simulator to protect minors online
Pérez Sánchez, Jaime; Balmaseda del Campo, Vicente; Urbistondo Murua, Ana Leticia Urbistondo Murua; Awad, Edmond; Castro Ponce, Mario; López López, GregorioIn this paper, we present a prototype framework that combines a custom-made interactive story-like serious game and non-parametric Bayesian modeling (where the generative part of the model is an Agent-based simulation) ... -
A computational framework for understanding risk factors in cybercrime
Pérez Sánchez, Jaime; Awad, Edmond; Castro Ponce, Mario; López López, Gregorio; Bueno Guerra, Nereida; Reneses Botija, María; Riberas Gutiérrez, María; Gómez Dorado, AarónIn this paper, we present a prototype computational framework to study the risk factors that play a relevant role in cybercrime. Intending to address the limitations of the classical approaches used in social science and ... -
A physicist’s approach to immunology
Castro Ponce, Mario (Springer (Berlín, Alemania), 2011-05-08) -
A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength
Rodriguez Bovolenta, Elena; García Cuesta, Eva M.; Horndler, Lydia; Ponomarenko, Julia; Schamel, Wolfgang W.; Mellado Garcia, Jose Mario; Castro Ponce, Mario; Abia Holgado, David; Van Santen, Hisse M. (2022-05-31)Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage ... -
A stochastic T cell response criterion
Currie, James; Castro Ponce, Mario; Lythe, Grant; Palmer, Ed; Molina París, Carmen (2012-11-07)The adaptive immune system relies on different cell types to provide fast and coordinated responses, characterized by recognition of pathogenic challenge, extensive cellular proliferation and differentiation, as well as ... -
A unifying mathematical framework for experimental TCR-pMHC kinetic constants
Faro Rivas, José Manuel; Castro Ponce, Mario; Molina París, Carmen (2017-04-26)Receptor binding and triggering are central in Immunology as T cells activated through their T cell receptors (TCR) by protein antigens orchestrate immune responses. In order to understand receptor-ligand interactions, ... -
A window of opportunity for cooperativity in the T cell receptor
Martín Blanco, Nadia; Blanco Domíguez, Raquel; Alda Catalinas, Celia; Rodriguez Bovolenta, Elena; Oeste, Clara Lillian; Palmer, Ed; Schamel, Wolfgang W.; Lythe, Grant; Molina París, Carmen; Castro Ponce, Mario; Alarcón Sánchez, Balbino (2018-12-01)The T-cell antigen receptor (TCR) is pre-organised in oligomers, known as nanoclusters. Nanoclusters could provide a framework for inter-TCR cooperativity upon peptide antigen-major histocompatibility complex (pMHC) binding. ... -
Adaptive polling enhances quality and energy saving for multimedia over Bluetooth
Contreras Bárcena, David; Castro Ponce, Mario (2011-05-01)Bluetooth has become an ubiquitous technology present in almost every electronic device. A question often asked by manufacturers and final users is whether it can be used for other uses different from the ones for which ... -
Affinity selection in germinal centers: cautionary tales and new opportunities
Faro Rivas, José Manuel; Castro Ponce, Mario (2021-05-01)Our current quantitative knowledge of the kinetics of antibody-mediated immunity is partly based on idealized experiments throughout the last decades. However, new experimental techniques often render contradictory ... -
Análisis de la complejidad del transporte de tráfico multimedia sobre piconets bluetooth
Contreras Bárcena, David; Castro Ponce, Mario (Sin editorial (Zaragoza, España), 2007-09-12) -
Anomalous ballistic scaling in the tensionless or inviscid Kardar-Parisi-Zhang equation
Rodríguez Fernández, Enrique; Santalla Arribas, Silvia Noemí; Castro Ponce, Mario; Cuerno Rejado, Rodolfo (2022-08-01)The one-dimensional Kardar-Parisi-Zhang (KPZ) equation is becoming an overarching paradigm for the scaling of nonequilibrium, spatially extended, classical and quantum systems with strong correlations. Recent analytical ... -
Apología de la vaca esférica: modelos sencillos para sistemas complejos
Castro Ponce, MarioEl éxito de la Ciencia de la Complejidad se debe, fundamentalmente, a su capacidad de explicar comportamientos emergentes y universales a partir de modelos relativamente sencillos. Por contra, en áreas afines como la ... -
Asymptotic behavior of a viscoelastic fluid in a closed loop thermosyphon: physical derivation, asymptotic analysis, and numerical experiments
Yasappan, Justine; Jiménez Casas, Ángela; Castro Ponce, Mario (2013-12-31)Fluids subject to thermal gradients produce complex behaviors that arise from the competition with gravitational effects. Although such sort of systems have been widely studied in the literature for simple (Newtonian) ... -
B cell receptors and free antibodies have different antigen-binding kinetics
García Sánchez, Miguel; Castro Ponce, Mario; Faro Rivas, José Manuel (2023-08-29)Since the pioneering works of Berg and Purcell, discriminating between diffusion followed by binding has played a central role in understanding cell signaling. B cell receptors (BCR) and antibodies (Ab) challenge that ... -
BCR-antigen catch bond behavior
Castro Ponce, Mario; García Sánchez, Miguel; Faro Rivas, José Manuel -
Brownian dynamics simulations of the B-cell activation
García Sánchez, Miguel; Castro Ponce, MarioThe binding between B cell receptors (BCRs) and their ligands is a fundamental step in the B cell activation. This binding consists of a series of states and processes which include: diffusion, orientation and molecular ... -
Causality guiding survey analysis: a use case on cyberbullying
Pérez Sánchez, Jaime; Awad, Edmond; Castro Ponce, Mario; López López, Gregorio -
CCR 5 deficiency impairs CD 4%2B T-cell memory responses and antigenic sensitivity through increased ceramide synthesis
Martín Leal, Ana; Blanco Fuentes, Raquel; Casas, Josefina; Sáez, María E.; Rodriguez Bovolenta, Elena; de Rojas, Itziar; Drechsler, Carina; Real Navarrete, Luis Miguel; Fabriàs Domingo, Gemma; Ruiz Laza, Agustín; Castro Ponce, Mario; Schamel, Wolfgang W.; Alarcón Sánchez, Balbino; Van Santen, Hisse M.; Mañes Broton, Santos (2020-08-03)CCR 5 is not only a coreceptor for HIV -1 infection in CD 4%2B T cells, but also contributes to their functional fitness. Here, we show that by limiting transcription of specific ceramide synthases, CCR 5 signaling reduces ... -
Challenges and opportunities in dock-based bike-sharing rebalancing: a systematic review
Vallez Fernández, Carlos Miguel; Castro Ponce, Mario; Contreras Bárcena, David (2021-02-02)Bike-sharing systems (BSS) have raised in popularity in the last years due to their potential share in sustainable cities. Although the first attempts to implement a bike-sharing public service date back to 1965 (Amsterdam), ... -
Cognate peptide-MHC complexes are expressed as tightly apposed nanoclusters in virus-infected cells to allow TCR crosslinking
Férez Ruiz, María; Castro Ponce, Mario; Alarcón Sánchez, Balbino; Van Santen, Hisse M. (2014-01-01)Antigenic T cell stimulation requires interaction between the TCR of the T cell and cognate peptide-MHC molecules presented by the APC. Although studies with TCR-specific Abs and soluble peptide-MHC ligands have shown that ...