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    • CCR 5 deficiency impairs CD 4%2B T-cell memory responses and antigenic sensitivity through increased ceramide synthesis 

      Martín Leal, Ana; Blanco Fuentes, Raquel; Casas, Josefina; Sáez, María E.; Rodriguez Bovolenta, Elena; de Rojas, Itziar; Drechsler, Carina; Real Navarrete, Luis Miguel; Fabriàs Domingo, Gemma; Ruiz Laza, Agustín; Castro Ponce, Mario; Schamel, Wolfgang W.; Alarcón Sánchez, Balbino; Van Santen, Hisse M.; Mañes Broton, Santos (2020-08-03)
      CCR 5 is not only a coreceptor for HIV -1 infection in CD 4%2B T cells, but also contributes to their functional fitness. Here, we show that by limiting transcription of specific ceramide synthases, CCR 5 signaling reduces ...