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Mostrando ítems 1-12 de 12

    • A stochastic T cell response criterion 

      Currie, James; Castro Ponce, Mario; Lythe, Grant; Palmer, Ed; Molina París, Carmen (2012-11-07)
      The adaptive immune system relies on different cell types to provide fast and coordinated responses, characterized by recognition of pathogenic challenge, extensive cellular proliferation and differentiation, as well as ...

    • A window of opportunity for cooperativity in the T cell receptor 

      Martín Blanco, Nadia; Blanco Domíguez, Raquel; Alda Catalinas, Celia; Rodriguez Bovolenta, Elena; Oeste, Clara Lillian; Palmer, Ed; Schamel, Wolfgang W.; Lythe, Grant; Molina París, Carmen; Castro Ponce, Mario; Alarcón Sánchez, Balbino (2018-12-01)
      The T-cell antigen receptor (TCR) is pre-organised in oligomers, known as nanoclusters. Nanoclusters could provide a framework for inter-TCR cooperativity upon peptide antigen-major histocompatibility complex (pMHC) binding. ...

    • Fate of a naive T cell: a stochastic journey 

      Higuera Romero, Luis de la; López García, Martín; Castro Ponce, Mario; Abourashchi, Niloufar; Lythe, Grant; Molina París, Carmen (2019-12-31)
      The homeostasis of T cell populations depends on migration, division and death of individual cells (1). T cells migrate between spatial compartments (spleen, lymph nodes, lung, liver, etc.), where they may divide or ...

    • First passage events in biological systems with non-exponential inter-event times 

      Castro Ponce, Mario; López García, Martín; Lythe, Grant; Molina París, Carmen (2018-12-01)
      It is often possible to model the dynamics of biological systems as a series of discrete transitions between a finite set of observable states (or compartments). When the residence times in each state, or inter-event times ...

    • Fusion and fission events regulate endosome maturation and viral escape 

      Castro Ponce, Mario; Lythe, Grant; Smit, Yolanda; Molina París, Carmen (2021-12-01)
      Endosomes are intracellular vesicles that mediate the communication of the cell with its extracellular environment. They are an essential part of the cell’s machinery regulating intracellular trafficking via the endocytic ...

    • Mathematics in modern immunology 

      Castro Ponce, Mario; Lythe, Grant; Molina París, Carmen; Ribeiro, Ruy M. (2016-04-06)
      Mathematical and statistical methods enable multidisciplinary approaches that catalyse discovery. Together with experimental methods, they identify key hypotheses, define measurable observables and reconcile disparate ...

    • Numerical experiments on noisy chains: From collective transitions to nucleation-diffusion 

      Castro Ponce, Mario; Lythe, Grant (2008-01-01)
      We consider chains of particles with nearest-neighbor coupling, independently subjected to noise, all initially in the same well of a symmetric double-well potential. If there are sufficiently few particles, transitions ...

    • On exact and approximate approaches for stochastic receptor-ligand competition dynamics - An ecological perspective 

      Jeffrey, Polly Anne; López García, Martín; Castro Ponce, Mario; Lythe, Grant; Molina París, Carmen (2020-06-01)
      Cellular receptors on the cell membrane can bind ligand molecules in the extra-cellular medium to form ligand-bound monomers. These interactions ultimately determine the fate of a cell through the resulting intra-cellular ...

    • Receptor pre-clustering and T cell responses: insights into molecular mechanisms 

      Castro Ponce, Mario; Van Santen, Hisse M.; Férez Ruiz, María; Alarcón Sánchez, Balbino; Lythe, Grant; Molina París, Carmen (2014-12-31)
      T cell activation, initiated by T cell receptor (TCR) mediated recognition of pathogen-derived peptides presented by major histocompatibility complex class I or II molecules (pMHC), shows exquisite specificity and sensitivity, ...

    • The T cells in an ageing virtual mouse 

      Castro Ponce, Mario; Lythe, Grant; Molina París, Carmen (Springer (Cham, Suiza), 2017-10-04)

    • Why are cell populations maintained via multiple compartments? 

      Feliciangeli, Flavia; Dreiwi, Hanan; López García, Martín; Castro Ponce, Mario; Molina París, Carmen; Lythe, Grant (2022-11-01)
      We consider the maintenance of ‘product’ cell populations from ‘progenitor’ cells via a sequence of one or more cell types, or compartments, where each cell’s fate is chosen stochastically. If there is only one compartment ...

    • Why are cell populations maintained via multiple compartments? 

      Feliciangeli, Flavia; Dreiwi, Hanan; López García, Martín; Castro Ponce, Mario; Molina París, Carmen; Lythe, Grant (01/11/2022)
      We consider the maintenance of ‘product’ cell populations from ‘progenitor’ cells via a sequence of one or more cell types, or compartments, where each cell’s fate is chosen stochastically. If there is only one compartment ...