Escolá Gascon, Alex Benito León, Julián 2025-10-23T10:21:26Z 2025-10-23T10:21:26Z 2025-04-26 2001-0370 https://doi.org/10.1016/j.csbj.2025.04.025 http://hdl.handle.net/11531/106686 Artículos en revistas . Quantum theories have long sought to explain conscious experience, yet their biggest challenge is not conceptual but methodological. A critical gap remains: the lack of statistical tools capable of empirically testing these theories against objective reality. This study introduces and formalizes the Q of Fisher-Escola ` distribution, the first statistical model to integrate quantum and classical probabilities, enabling robust inferential analysis in neuroscience and consciousness studies. We examined 150 density matrices of entangled states in a 10-qubit quantum system using IBM’s quantum supercomputers. Through maximum likelihood estimation, we mathematically confirmed that QFisher-Escola ` ~ beta(a, b, loc, scale). As a key contribution, a novel analytical solution to the Quantum Fisher Information (QFI) integral was derived, improving decoherence stability. Additionally, 10⁵ Monte Carlo simulations allowed us to establish critical thresholds for α = 0.05, 0.01, 0.001, and 0.0001, while assessing Type I and II error rates. Type I errors appeared in 2–5 % of right-tailed tests at α = 0.05 but approached zero as α decreased. Type II errors occurred in left-tailed tests (1–4 % at α = 0.05) but also diminished with stricter significance levels. In two-tailed tests, both error types remained below 3 %, highlighting the distribution’s robustness. The Q of Fisher-Escola ` distribution pioneers a statistical framework for modeling quantum-classical interactions in consciousness research. It enables hypothesis testing and predicting subjective experiences, with applications in neuroscience and computational automation. Supported by mathematical proofs and empirical validation, this model advances the integration of quantum probability into neuroscience. application/pdf en-GB Creative Commons Reconocimiento-NoComercial-SinObraDerivada España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Revista: Computational and Structural Biotechnology Journal, Periodo: 1, Volumen: 30, Número: , Página inicial: 41, Página final: 58 Mathematical proof of the Fisher-Escola ` Q statistical distribution in quantum consciousness modeling info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess . Quantum consciousness Quantum Fisher Information Hypothesis testing Q Fisher-Escola ` Distribution Quantum entanglement