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CCR 5 deficiency impairs CD 4%2B T-cell memory responses and antigenic sensitivity through increased ceramide synthesis
dc.contributor.author | Martín Leal, Ana | es-ES |
dc.contributor.author | Blanco Fuentes, Raquel | es-ES |
dc.contributor.author | Casas, Josefina | es-ES |
dc.contributor.author | Sáez, María E. | es-ES |
dc.contributor.author | Rodriguez Bovolenta, Elena | es-ES |
dc.contributor.author | de Rojas, Itziar | es-ES |
dc.contributor.author | Drechsler, Carina | es-ES |
dc.contributor.author | Real Navarrete, Luis Miguel | es-ES |
dc.contributor.author | Fabriàs Domingo, Gemma | es-ES |
dc.contributor.author | Ruiz Laza, Agustín | es-ES |
dc.contributor.author | Castro Ponce, Mario | es-ES |
dc.contributor.author | Schamel, Wolfgang W. | es-ES |
dc.contributor.author | Alarcón Sánchez, Balbino | es-ES |
dc.contributor.author | Van Santen, Hisse M. | es-ES |
dc.contributor.author | Mañes Broton, Santos | es-ES |
dc.date.accessioned | 2021-06-07T11:54:56Z | |
dc.date.available | 2021-06-07T11:54:56Z | |
dc.date.issued | 2020-08-03 | es_ES |
dc.identifier.issn | 0261-4189 | es_ES |
dc.identifier.uri | https:doi.org10.15252embj.2020104749 | es_ES |
dc.description | Artículos en revistas | es_ES |
dc.description.abstract | es-ES | |
dc.description.abstract | CCR 5 is not only a coreceptor for HIV -1 infection in CD 4%2B T cells, but also contributes to their functional fitness. Here, we show that by limiting transcription of specific ceramide synthases, CCR 5 signaling reduces ceramide levels and thereby increases T-cell antigen receptor (TCR ) nanoclustering in antigen-experienced mouse and human CD 4%2B T cells. This activity is CCR 5-specific and independent of CCR 5 co-stimulatory activity. CCR 5-deficient mice showed reduced production of high-affinity class-switched antibodies, but only after antigen rechallenge, which implies an impaired memory CD 4%2B T-cell response. This study identifies a CCR 5 function in the generation of CD 4%2B T-cell memory responses and establishes an antigen-independent mechanism that regulates TCR nanoclustering by altering specific lipid species. | en-GB |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | en-GB | es_ES |
dc.source | Revista: EMBO Journal, Periodo: 1, Volumen: online, Número: 15, Página inicial: e104749-1, Página final: e104749-19 | es_ES |
dc.subject.other | Instituto de Investigación Tecnológica (IIT) | es_ES |
dc.title | CCR 5 deficiency impairs CD 4%2B T-cell memory responses and antigenic sensitivity through increased ceramide synthesis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.rights.holder | es_ES | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.keywords | es-ES | |
dc.keywords | ccr5[delta]32; humoral response; membrane phase; sphingolipid;T-cell receptor | en-GB |
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