Grape Polyphenols to Arrest in Vitro Proliferation of Human Leukemia Cells: A Systematic Review and Meta-analysis
Abstract
. Leukemia is a heterogeneous group of hemopoietic cancers, which accounts
for 2.6% of new cases per year of total cancer incidence worldwide. Grapes
and grape-derived products, such as grape juice, are naturally rich in polyphenols, bioactive compounds with antioxidant properties. Certain polyphenols have been proved to alter oxidative balance, both in inducing apoptosis
in cancer cells and in preventing cancer development via controlling oxidative stress. To assess the therapeutic potential of grape polyphenols in the
treatment of leukemia, a systematic review and meta-analysis of the reported
data on leukemia was carried out. Following the PRISMA guide, a literature
review of published papers on leukemia and polyphenols from the last
50 years was conducted, and 17 scientific articles published from 2002 to
2017 were included in the study. Resveratrol 50 μM had the highest growth
inhibition effect (67%) followed by quercetin (30%). The results also point to
a differential effect of polyphenols based on cell lineage; monocytes- and
myelocytic-derived cell lines are the most susceptible, with a mean of 85%
and 64% proliferation inhibition, respectively. Moreover, results show that
growth inhibition cannot be associated with a molecular effect of polyphenols on the cell cycle arrest.