Keywords
Bifidobacterium breve, Probiótico, Leche humana, Microbioma infantil, Nutrición infantil, Bifidobacterium breve, Probiotic, Human milk, Infant microbiome, Infant nutrition
Exploring the Potential Probiotic Properties of Bifidobacterium breve DSM 32583—A Novel Strain Isolated from Human Milk
Abstract
La leche materna constituye la mejor fuente de nutrición para los lactantes y un importante reservorio de bacterias beneficiosas con potencial probiótico. Este estudio evaluó las propiedades funcionales de la nueva cepa Bifidobacterium breve DSM 32583, aislada de leche humana. Los autores analizaron su resistencia a las condiciones del tracto gastrointestinal, su capacidad de adhesión a células epiteliales, la inhibición del crecimiento de microorganismos potencialmente patógenos, el perfil de resistencia a antibióticos y la seguridad genómica. Además, se estudió su capacidad para metabolizar oligosacáridos de la leche humana y producir compuestos bioactivos. Los resultados muestran que la cepa presenta características compatibles con un candidato probiótico seguro, sin genes de virulencia ni plásmidos, y con propiedades funcionales que respaldan su posible aplicación en productos destinados a la nutrición infantil.
Human milk is the best nutrition for infants, providing optimal support for the developing immune system and gut microbiota. Hence, it has been used as source for probiotic strain isolation, including members of the genus Bifidobacterium, in an effort to provide beneficial effects to infants who cannot be exclusively breastfed. However, not all supplemented bifidobacteria can effectively colonise the infant gut, nor confer health benefits to the individual infant host; therefore, new isolates are needed to develop a range of dietary products for this specific age group. Here, we investigated the beneficial potential of Bifidobacterium breve DSM 32583 isolated from human milk. We show that in vitro the strain exhibited several characteristics considered fundamental for beneficial bacteria, including survival under simulated gastrointestinal conditions, adherence to human epithelial cells and inhibition of potentially pathogenic microorganisms, supporting its potential as a probiotic candidate.
Human milk is the best nutrition for infants, providing optimal support for the developing immune system and gut microbiota. Hence, it has been used as source for probiotic strain isolation, including members of the genus Bifidobacterium, in an effort to provide beneficial effects to infants who cannot be exclusively breastfed. However, not all supplemented bifidobacteria can effectively colonise the infant gut, nor confer health benefits to the individual infant host; therefore, new isolates are needed to develop a range of dietary products for this specific age group. Here, we investigated the beneficial potential of Bifidobacterium breve DSM 32583 isolated from human milk. We show that in vitro the strain exhibited several characteristics considered fundamental for beneficial bacteria, including survival under simulated gastrointestinal conditions, adherence to human epithelial cells and inhibition of potentially pathogenic microorganisms, supporting its potential as a probiotic candidate.
Información detallada
Materias, derechos, colecciones e identificadores
URI / Handle
10.1007/s12602-024-10346-9Rights
Creative Commons Reconocimiento-NoComercial-SinObraDerivada España