Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/11531/5447
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Castro Ponce, Mario | es-ES |
dc.contributor.author | Van Santen, Hisse M. | es-ES |
dc.contributor.author | Férez Ruiz, María | es-ES |
dc.contributor.author | Alarcón Sánchez, Balbino | es-ES |
dc.contributor.author | Lythe, Grant | es-ES |
dc.contributor.author | Molina París, Carmen | es-ES |
dc.date.accessioned | 2016-01-15T11:20:45Z | - |
dc.date.available | 2016-01-15T11:20:45Z | - |
dc.date.issued | 2014-12-31 | es_ES |
dc.identifier.issn | 1664-3224 | es_ES |
dc.identifier.uri | https:doi.org10.3389fimmu.2014.00132 | es_ES |
dc.description | Artículos en revistas | es_ES |
dc.description.abstract | es-ES | |
dc.description.abstract | T cell activation, initiated by T cell receptor (TCR) mediated recognition of pathogen-derived peptides presented by major histocompatibility complex class I or II molecules (pMHC), shows exquisite specificity and sensitivity, even though the TCR-pMHC binding interaction is of low affinity. Recent experimental work suggests that TCR pre-clustering may be a mechanism via which T cells can achieve such high sensitivity. The unresolved stoichiometry of the TCR makes TCR-pMHC binding and TCR triggering, an open question. We formulate a mathematical model to characterize the pre-clustering of T cell receptors (TCRs) on the surface of T cells, motivated by the experimentally observed distribution of TCR clusters on the surface of naive and memory T cells. We extend a recently introduced stochastic criterion to compute the timescales of T cell responses, assuming that ligand-induced cross-linked TCR is the minimum signaling unit. We derive an approximate formula for the mean time to signal initiation. Our results show that pre-clustering reduces the mean activation time. However, additional mechanisms favoring the existence of clusters are required to explain the difference between naive and memory T cell responses. We discuss the biological implications of our results, and both the compatibility and complementarity of our approach with other existing mathematical models. | en-GB |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | en-GB | es_ES |
dc.source | Revista: Frontiers in Immunology, Periodo: 1, Volumen: online, Número: , Página inicial: 132-1, Página final: 132-11 | es_ES |
dc.subject.other | Instituto de Investigación Tecnológica (IIT) | es_ES |
dc.title | Receptor pre-clustering and T cell responses: insights into molecular mechanisms | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.rights.holder | es_ES | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.keywords | es-ES | |
dc.keywords | T cell receptor, clustering, stochastic dynamics, signaling, naive T cells, memory T cells | en-GB |
dc.identifier.doi | 10.3389/fimmu.2014.00132 | es_ES |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
IIT-14-033A.pdf | 1,58 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.