Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/11531/56098
Título : | CCR 5 deficiency impairs CD 4%2B T-cell memory responses and antigenic sensitivity through increased ceramide synthesis |
Autor : | Martín Leal, Ana Blanco Fuentes, Raquel Casas, Josefina Sáez, María E. Rodriguez Bovolenta, Elena de Rojas, Itziar Drechsler, Carina Real Navarrete, Luis Miguel Fabriàs Domingo, Gemma Ruiz Laza, Agustín Castro Ponce, Mario Schamel, Wolfgang W. Alarcón Sánchez, Balbino Van Santen, Hisse M. Mañes Broton, Santos |
Fecha de publicación : | 3-ago-2020 |
Resumen : | CCR 5 is not only a coreceptor for HIV -1 infection in CD 4%2B T cells, but also contributes to their functional fitness. Here, we show that by limiting transcription of specific ceramide synthases, CCR 5 signaling reduces ceramide levels and thereby increases T-cell antigen receptor (TCR ) nanoclustering in antigen-experienced mouse and human CD 4%2B T cells. This activity is CCR 5-specific and independent of CCR 5 co-stimulatory activity. CCR 5-deficient mice showed reduced production of high-affinity class-switched antibodies, but only after antigen rechallenge, which implies an impaired memory CD 4%2B T-cell response. This study identifies a CCR 5 function in the generation of CD 4%2B T-cell memory responses and establishes an antigen-independent mechanism that regulates TCR nanoclustering by altering specific lipid species. |
Descripción : | Artículos en revistas |
URI : | https:doi.org10.15252embj.2020104749 |
ISSN : | 0261-4189 |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
IIT-20-055A.pdf | 2,6 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.