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Microencapsulation of rifampicin: a technique to preserve the mechanical properties of bone cement
dc.contributor.author | Sanz Ruiz, Pablo | es-ES |
dc.contributor.author | Carbó Laso, Esther | es-ES |
dc.contributor.author | del Real Romero, Juan Carlos | es-ES |
dc.contributor.author | Arán Ais, Francisca | es-ES |
dc.contributor.author | Ballesteros Iglesias, María Yolanda | es-ES |
dc.contributor.author | Paz Jiménez, Eva | es-ES |
dc.contributor.author | Sánchez Navarro, Mª Magdalena | es-ES |
dc.contributor.author | Pérez Limiñana, Mª Ángeles | es-ES |
dc.contributor.author | Vaquero Martín, Javier | es-ES |
dc.date.accessioned | 2017-12-21T15:45:34Z | |
dc.date.available | 2017-12-21T15:45:34Z | |
dc.date.issued | 2018-01-01 | es_ES |
dc.identifier.issn | 0736-0266 | es_ES |
dc.identifier.uri | https:doi.org10.1002jor.23614 | es_ES |
dc.description | Artículos en revistas | es_ES |
dc.description.abstract | es-ES | |
dc.description.abstract | Two-stage exchange with antibiotic-loaded bone cement spacers remains the gold standard for chronic periprosthetic joint infection (PJI). Rifampicin is highly efficient on stationary-phase staphylococci in biofilm; however, its addition to PMMA to manufacture spacers prevents polymerization and reduces mechanical properties. Isolation of rifampicin during polymerization by microencapsulation could allow manufacturing rifampicin-loaded bone cement maintaining elution and mechanical properties. Microcapsules of rifampicin with alginate, polyhydroxybutyratehydroxyvalerate (PHBV), ethylcellulose and stearic acid (SA) were synthesized. Alginate and PHBV microcapsules were added to bone cement and elution, compression, bending, hardness, setting time and microbiological tests were performed. Repeated measures ANOVA and Bonferroni post-hoc test were performed, considering a p | en-GB |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | en-GB | es_ES |
dc.rights | es_ES | |
dc.rights.uri | es_ES | |
dc.source | Revista: Journal of Orthopaedic Research, Periodo: 1, Volumen: online, Número: 1, Página inicial: 459, Página final: 466 | es_ES |
dc.subject.other | Instituto de Investigación Tecnológica (IIT) | es_ES |
dc.title | Microencapsulation of rifampicin: a technique to preserve the mechanical properties of bone cement | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.rights.holder | es_ES | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.keywords | es-ES | |
dc.keywords | Rifampicin-loaded bone cement; rifampicin microencapsulation; bone cement spacers; periprosthetic infection | en-GB |
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