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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Jeffrey, Polly Anne | es-ES |
dc.contributor.author | López García, Martín | es-ES |
dc.contributor.author | Castro Ponce, Mario | es-ES |
dc.contributor.author | Lythe, Grant | es-ES |
dc.contributor.author | Molina París, Carmen | es-ES |
dc.date.accessioned | 2021-06-07T11:56:05Z | - |
dc.date.available | 2021-06-07T11:56:05Z | - |
dc.date.issued | 2020-06-01 | es_ES |
dc.identifier.issn | 2227-7390 | es_ES |
dc.identifier.uri | https:doi.org10.3390math8061014 | es_ES |
dc.description | Artículos en revistas | es_ES |
dc.description.abstract | es-ES | |
dc.description.abstract | Cellular receptors on the cell membrane can bind ligand molecules in the extra-cellular medium to form ligand-bound monomers. These interactions ultimately determine the fate of a cell through the resulting intra-cellular signalling cascades. Often, several receptor types can bind a shared ligand leading to the formation of different monomeric complexes, and in turn to competition for the common ligand. Here, we describe competition between two receptors which bind a common ligand in terms of a bi-variate stochastic process. The stochastic description is important to account for fluctuations in the number of molecules. Our interest is in computing two summary statistics—the steady-state distribution of the number of bound monomers and the time to reach a threshold number of monomers of a given kind. The matrix-analytic approach developed in this manuscript is exact, but becomes impractical as the number of molecules in the system increases. Thus, we present novel approximations which can work under low-to-moderate competition scenarios. Our results apply to systems with a larger number of population species (i.e., receptors) competing for a common resource (i.e., ligands), and to competition systems outside the area of molecular dynamics, such as Mathematical Ecology. | en-GB |
dc.format.mimetype | application/pdf | es_ES |
dc.language.iso | en-GB | es_ES |
dc.source | Revista: Mathematics, Periodo: 1, Volumen: online, Número: 6, Página inicial: 1014-1, Página final: 1014-31 | es_ES |
dc.subject.other | Instituto de Investigación Tecnológica (IIT) | es_ES |
dc.title | On exact and approximate approaches for stochastic receptor-ligand competition dynamics - An ecological perspective | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.rights.holder | es_ES | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.keywords | es-ES | |
dc.keywords | receptor-ligand interaction; continuous-time Markov chain; summary statistics; steady-state; first-passage time; approximation | en-GB |
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IIT-20-060A.pdf | 15,41 MB | Adobe PDF | ![]() Visualizar/Abrir |
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