Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/11531/56109
Título : | On exact and approximate approaches for stochastic receptor-ligand competition dynamics - An ecological perspective |
Autor : | Jeffrey, Polly Anne López García, Martín Castro Ponce, Mario Lythe, Grant Molina París, Carmen |
Fecha de publicación : | 1-jun-2020 |
Resumen : | Cellular receptors on the cell membrane can bind ligand molecules in the extra-cellular medium to form ligand-bound monomers. These interactions ultimately determine the fate of a cell through the resulting intra-cellular signalling cascades. Often, several receptor types can bind a shared ligand leading to the formation of different monomeric complexes, and in turn to competition for the common ligand. Here, we describe competition between two receptors which bind a common ligand in terms of a bi-variate stochastic process. The stochastic description is important to account for fluctuations in the number of molecules. Our interest is in computing two summary statistics—the steady-state distribution of the number of bound monomers and the time to reach a threshold number of monomers of a given kind. The matrix-analytic approach developed in this manuscript is exact, but becomes impractical as the number of molecules in the system increases. Thus, we present novel approximations which can work under low-to-moderate competition scenarios. Our results apply to systems with a larger number of population species (i.e., receptors) competing for a common resource (i.e., ligands), and to competition systems outside the area of molecular dynamics, such as Mathematical Ecology. |
Descripción : | Artículos en revistas |
URI : | https:doi.org10.3390math8061014 |
ISSN : | 2227-7390 |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
IIT-20-060A.pdf | 15,41 MB | Adobe PDF | ![]() Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.