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Microencapsulation of rifampicin: a technique to preserve the mechanical properties of bone cement

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IIT-17-114A.pdf (25.22Mb)
Fecha
2018-01-01
Autor
Sanz Ruiz, Pablo
Carbó Laso, Esther
del Real Romero, Juan Carlos
Arán Ais, Francisca
Ballesteros Iglesias, María Yolanda
Paz Jiménez, Eva
Sánchez Navarro, Mª Magdalena
Pérez Limiñana, Mª Ángeles
Vaquero Martín, Javier
Estado
info:eu-repo/semantics/publishedVersion
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Two-stage exchange with antibiotic-loaded bone cement spacers remains the gold standard for chronic periprosthetic joint infection (PJI). Rifampicin is highly efficient on stationary-phase staphylococci in biofilm; however, its addition to PMMA to manufacture spacers prevents polymerization and reduces mechanical properties. Isolation of rifampicin during polymerization by microencapsulation could allow manufacturing rifampicin-loaded bone cement maintaining elution and mechanical properties. Microcapsules of rifampicin with alginate, polyhydroxybutyratehydroxyvalerate (PHBV), ethylcellulose and stearic acid (SA) were synthesized. Alginate and PHBV microcapsules were added to bone cement and elution, compression, bending, hardness, setting time and microbiological tests were performed. Repeated measures ANOVA and Bonferroni post-hoc test were performed, considering a p
 
URI
https:doi.org10.1002jor.23614
Microencapsulation of rifampicin: a technique to preserve the mechanical properties of bone cement
Tipo de Actividad
Artículos en revistas
ISSN
0736-0266
Materias/ categorías / ODS
Instituto de Investigación Tecnológica (IIT)
Palabras Clave

Rifampicin-loaded bone cement; rifampicin microencapsulation; bone cement spacers; periprosthetic infection
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Repositorio de la Universidad Pontificia Comillas copyright © 2015  Desarrollado con DSpace Software
Contacto | Sugerencias